Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
USERS' SCORE
Good
Based on 23 Reviews
8.3
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Magnesium (from Magnesium Aspartate)
250 mg
60%
Potassium (from Potassium Aspartate)
99 mg
2%
Taurine (Free-Form)
100 mg
†
Top Medical Research Studies
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
8
Riluzole effectively reduces bone pain
We explored whether riluzole could help ease bone pain caused by prostate cancer. Using a mouse model that mimicked human bone cancer pain, we treated some mice with riluzole while others were not.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
Read More
8
We explored a unique case where a 39-year-old man presented with severe bone pain due to Sjögren's syndrome-related renal issues. He also exhibited symptoms like polydipsia and hypophosphatemic osteomalacia. After one month of potassium, phosphate, vitamin D, and sodium bicarbonate supplements, we observed significant relief in his bone pain, alongside normalized potassium and phosphorus levels. This indicates that potassium intake can play a crucial role in alleviating bone pain linked to kidney dysfunction in autoimmune conditions, such as Sjögren's syndrome.
Read More
Most Useful Reviews
9
Pain relief miracle
26 people found this helpful
He saved me! I initially laughed when my wife said I twitched in my sleep. However, when I experienced numbness in my fingers and cramping in my calf muscles, I was no longer amused. After a month of daily calcium and magnesium intake, everything improved dramatically. By the fifth day, the calf pain subsided, allowing me to stretch in bed without fearing severe discomfort. Although the numbness persists, it has lessened significantly. At 60, I’m grateful for vitamins that help restore normalcy in life. These vitamins are now a staple for me.
Read More
9
Holistic health support
11 people found this helpful
I am thrilled with my experience using magnesium! I take it several times a year and find it aids in falling asleep quickly and improving my overall mood. I also noticed relief from bone pain and effective management of PMS symptoms. Magnesium helps my body tackle inflammation and enhances cardiovascular health, making it a remarkable product that I highly recommend.
Read More
9
Remarkable improvement
9 people found this helpful
Initially, I laughed when my wife noted my nightly twitching. However, after experiencing painful calf cramps and numb fingers, I sought help. The daily intake of calcium and magnesium over a month transformed my situation. The calf issue resolved within five days, allowing me to stretch comfortably in bed again. The numbness persists, though less painfully. At 45, I appreciate having these supportive vitamins in my life. They’ll always be with me. If you found this helpful, please click Yes.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.3
- All Researches
8
Riluzole effectively reduces bone pain
We explored whether riluzole could help ease bone pain caused by prostate cancer. Using a mouse model that mimicked human bone cancer pain, we treated some mice with riluzole while others were not.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
Our findings indicated that riluzole significantly reduced pain sensitivity without hindering cancer progression or bone health. This treatment seems effective in offering relief from unpleasant pain sensations associated with bone metastases.
Read More
8
We explored a unique case where a 39-year-old man presented with severe bone pain due to Sjögren's syndrome-related renal issues. He also exhibited symptoms like polydipsia and hypophosphatemic osteomalacia. After one month of potassium, phosphate, vitamin D, and sodium bicarbonate supplements, we observed significant relief in his bone pain, alongside normalized potassium and phosphorus levels. This indicates that potassium intake can play a crucial role in alleviating bone pain linked to kidney dysfunction in autoimmune conditions, such as Sjögren's syndrome.
Read More
8
We examined the effects of low-dose adefovir therapy on bone pain in patients showing signs of nephrogenic hypophosphatemic osteomalacia. Over two years, five patients developed reduced phosphate levels and renal issues, leading to bone pain. After stopping the treatment and providing phosphate and potassium supplements, we noticed significant decreases in bone pain and improved mobility in some patients. This indicates that potassium treatment, alongside phosphate supplementation, can positively affect bone pain related to kidney issues stemming from adefovir.
Read More
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 23 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Pain relief miracle
26 people found this helpful
He saved me! I initially laughed when my wife said I twitched in my sleep. However, when I experienced numbness in my fingers and cramping in my calf muscles, I was no longer amused. After a month of daily calcium and magnesium intake, everything improved dramatically. By the fifth day, the calf pain subsided, allowing me to stretch in bed without fearing severe discomfort. Although the numbness persists, it has lessened significantly. At 60, I’m grateful for vitamins that help restore normalcy in life. These vitamins are now a staple for me.
Read More
9
Holistic health support
11 people found this helpful
I am thrilled with my experience using magnesium! I take it several times a year and find it aids in falling asleep quickly and improving my overall mood. I also noticed relief from bone pain and effective management of PMS symptoms. Magnesium helps my body tackle inflammation and enhances cardiovascular health, making it a remarkable product that I highly recommend.
Read More
9
Remarkable improvement
9 people found this helpful
Initially, I laughed when my wife noted my nightly twitching. However, after experiencing painful calf cramps and numb fingers, I sought help. The daily intake of calcium and magnesium over a month transformed my situation. The calf issue resolved within five days, allowing me to stretch comfortably in bed again. The numbness persists, though less painfully. At 45, I appreciate having these supportive vitamins in my life. They’ll always be with me. If you found this helpful, please click Yes.
Read More
9
Joint pain relief
4 people found this helpful
This product has significantly improved my joint and muscle pains. I started using it two weeks ago, and my sleep quality has drastically improved. It also helps with hormonal imbalance and has no unpleasant taste, making it easy to swallow before bedtime.
Read More
7.5
Muscle pain relief
3 people found this helpful
My husband experienced muscle spasms while on cholesterol-lowering drugs, which deplete essential elements like potassium and magnesium. I chose this specific product due to its optimal composition and reasonable price. Remarkably, he felt relief within just one day of taking it. Highly recommended!
Read More
Frequently Asked Questions
9
Pain relief miracle
26 people found this helpful
He saved me! I initially laughed when my wife said I twitched in my sleep. However, when I experienced numbness in my fingers and cramping in my calf muscles, I was no longer amused. After a month of daily calcium and magnesium intake, everything improved dramatically. By the fifth day, the calf pain subsided, allowing me to stretch in bed without fearing severe discomfort. Although the numbness persists, it has lessened significantly. At 60, I’m grateful for vitamins that help restore normalcy in life. These vitamins are now a staple for me.
7.5
Effective treatment
10 people found this helpful
It took about 2-3 weeks, but this product almost eliminated my muscle pain. I also recommended it to my mother, who is 74 and has suffered from significant muscle discomfort in her legs. I sincerely hope it helps her as well.
9
Remarkable improvement
9 people found this helpful
Initially, I laughed when my wife noted my nightly twitching. However, after experiencing painful calf cramps and numb fingers, I sought help. The daily intake of calcium and magnesium over a month transformed my situation. The calf issue resolved within five days, allowing me to stretch comfortably in bed again. The numbness persists, though less painfully. At 45, I appreciate having these supportive vitamins in my life. They’ll always be with me. If you found this helpful, please click Yes.
7.5
Muscle pain relief
3 people found this helpful
My husband experienced muscle spasms while on cholesterol-lowering drugs, which deplete essential elements like potassium and magnesium. I chose this specific product due to its optimal composition and reasonable price. Remarkably, he felt relief within just one day of taking it. Highly recommended!
9
Joint pain relief
4 people found this helpful
This product has significantly improved my joint and muscle pains. I started using it two weeks ago, and my sleep quality has drastically improved. It also helps with hormonal imbalance and has no unpleasant taste, making it easy to swallow before bedtime.
9
Holistic health support
11 people found this helpful
I am thrilled with my experience using magnesium! I take it several times a year and find it aids in falling asleep quickly and improving my overall mood. I also noticed relief from bone pain and effective management of PMS symptoms. Magnesium helps my body tackle inflammation and enhances cardiovascular health, making it a remarkable product that I highly recommend.
9
Reduced neck pain
7 people found this helpful
Helped me, I was looking for a combination of magnesium with potassium, which I found in this preparation, plus taurine. I took 2-4 tablets daily. A couple of weeks after starting, the bone pain in my neck almost disappeared, and my legs improved as well. I read concerns about this form of magnesium being poorly absorbed, but it worked for me and was beneficial, so I will likely order again.
7.5
Enhanced bone health
1 people found this helpful
My mother took this just before bed, and not only did she stop snoring (which was a relief for me), but her mood was noticeably better the following morning! I quickly recommended she continue with this supplement. Combined with magnesium, it seems to be absorbed more easily than a potassium-only supplement. Over the following months, we witnessed improvements in her bone health, including better posture, more stable movements, and straighter bones.
7.5
Immediate effect
1 people found this helpful
This is a truly wonderful product! It allows you to experience the effects almost immediately, providing prolonged action for bone and joint health.
7.5
Joint pain reduced
This product greatly reduced my joint pain. Despite some unrelated text, I found its effectiveness beyond expectations for alleviating discomfort.
9
Better sleep quality
The main advantage of this supplement is improved sleep quality. No more nighttime bone pain in my legs.
9
Joint pain help
1 people found this helpful
I have thyroid issues requiring potassium and magnesium supplements, which have significantly improved my sleep and alleviated muscle and joint pain. I hope to continue as it has helped me immensely with chronic pain and sleep deficits.
7
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
7
Promising drug delivery for osteoporosis
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
8
We explored a unique case where a 39-year-old man presented with severe bone pain due to Sjögren's syndrome-related renal issues. He also exhibited symptoms like polydipsia and hypophosphatemic osteomalacia. After one month of potassium, phosphate, vitamin D, and sodium bicarbonate supplements, we observed significant relief in his bone pain, alongside normalized potassium and phosphorus levels. This indicates that potassium intake can play a crucial role in alleviating bone pain linked to kidney dysfunction in autoimmune conditions, such as Sjögren's syndrome.
8
We examined the effects of low-dose adefovir therapy on bone pain in patients showing signs of nephrogenic hypophosphatemic osteomalacia. Over two years, five patients developed reduced phosphate levels and renal issues, leading to bone pain. After stopping the treatment and providing phosphate and potassium supplements, we noticed significant decreases in bone pain and improved mobility in some patients. This indicates that potassium treatment, alongside phosphate supplementation, can positively affect bone pain related to kidney issues stemming from adefovir.
References
- Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. doi:10.3389/fbioe.2023.1153969
- Jakubowska-Pietkiewicz E, Chlebna-Sokół D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
- Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.
- Chen R, Fang L, Fang X, Ning J. Sjögren's syndrome complicated with hypothyroidism and osteomalacia: A case report. Medicine (Baltimore). 2024;103:e39771. doi:10.1097/MD.0000000000039771
- Delanne-Cuménal M, Lamoine S, Meleine M, Aissouni Y, Prival L, et al. The TREK-1 potassium channel is involved in both the analgesic and anti-proliferative effects of riluzole in bone cancer pain. Biomed Pharmacother. 2024;176:116887. doi:10.1016/j.biopha.2024.116887
- Filler G, Schott C, Salerno FR, Ens A, McIntyre CW, et al. Growth hormone therapy in HHRH. Bone Rep. 2022;16:101591. doi:10.1016/j.bonr.2022.101591
- Geng Y, Zhao Y, Zhang Z. Tubulointerstitial nephritis-induced hypophosphatemic osteomalacia in Sjögren's syndrome: a case report and review of the literature. Clin Rheumatol. 2018;37:257. doi:10.1007/s10067-017-3762-y
- Xu Y, Shen P, Pan X, Chen N. Nephrogenic hypophosphatemic osteomalacia during adefovir monotherapy for chronic hepatitis B monoinfection. Clin Kidney J. 2013;6:379. doi:10.1093/ckj/sft069
- Earle KE, Seneviratne T, Shaker J, Shoback D. Fanconi's syndrome in HIV+ adults: report of three cases and literature review. J Bone Miner Res. 2004;19:714.
